Table 2. Pathogenicity and replication of a reassortant H7N9/PR8 virus in BALB/c micea.
| Virus | Mean virus titer (log10TCID50) on day 3 post-inoculation | ||||
| Lung | Brain | Spleen | Liver | Kidney | |
| PR8 | 5.7±0.12 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0c |
| AnHui 01 | 5.4±0.11 | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 |
| H7N9/PR8 | 4.6±0.10b | ≤1.0 | ≤1.0 | ≤1.0 | ≤1.0 |
a
BALB/c mice were inoculated intranasally with 106 EID50 of the indicated viruses and euthanized 3 days later. Virus titers in lung, brain, spleen, and liver tissue were determined by titration in MDCK cells. Geometric mean titers ± SDs are shown.
b
p<0.01 compared with the tiers in the corresponding organs of the AnHui 01 or PR8-inoculated mice.
c
The lower limit of detection was 10 TCID50/g of tissue.