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. 2014 Jun 17;9(6):e99844. doi: 10.1371/journal.pone.0099844

Figure 2. Reviewing evidence of GC-bias in ChIP-seq data.

Figure 2

The GC-content was determined for various classes of genomic regions. The GC-content distribution per class is shown in boxplots (whiskers range from 2.5 to 97.5%). A. The GC-content distribution of various classes of regulatory elements is plotted next that of random genomic regions (genome background). B. The GC-content distribution of genomic regions covered by single tags, resulting from various ChIP-seq experiments, is plotted. The red dotted lines indicate the inter-quartile range of the genome background. C. The GC-content distribution of genomic regions covered by tag accumulations (30–40 tags), resulting from various ChIP-seq experiments, is plotted. The green dotted lines indicate the inter-quartile range of validated cardiac enhancers.