Table 3. Site-specific cancers risk after basal cell and squamous cell skin cancers versus controls.
| Cancer site | Controls | BCC vs controls | SCC vs controls | |||
| N = 1341 | N = 1,363 | N = 880 | ||||
| Number withcancer | Number withcancer | HR (95% CI) | Number withcancer | HR (95% CI) | ||
| All cancers | All | 186 | 213 | 1.40 (1.15, 1.71) | 161 | 1.18 (0.95, 1.46) |
| Men only | 121 | 140 | 1.55 (1.21, 1.99) | 110 | 1.17 (0.90,1.52) | |
| Women only | 65 | 73 | 1.14 (0.81, 1.60) | 51 | 1.22 (0.84, 1.79) | |
| <60 y | 40 | 64 | 1.31 (0.88, 1.95) | 39 | 1.96 (1.24, 3.12) | |
| ≥60 y | 146 | 149 | 1.43 (1.14, 1.80) | 122 | 1.00 (0.79, 1.28) | |
| All cancers exceptmelanoma | All | 177 | 180 | 1.24 (1.01, 1.54) | 136 | 1.01 (0.81, 1.27) |
| Men only | 115 | 117 | 1.37 (1.05, 1.78) | 91 | 0.98 (0.74, 1.30) | |
| Women only | 62 | 63 | 1.03 (0.72, 1.48) | 45 | 1.11 (0.74, 1.30) | |
| <60 y | 35 | 50 | 1.17 (0.76, 1.82) | 29 | 1.67 (0.99, 2.81) | |
| ≥60 y | 142 | 130 | 1.27 (1.00, 1.61) | 107 | 0.89 (0.69, 1.15) | |
| Melanoma | All | 15 | 63 | 3.28 (1.66, 6.51) 1 | 42 | 3.62 (1.85. 7.11) 2 |
| Men only | 12 | 46 | 3.19 (1.48, 6.91) | 32 | 3.53 (1.63, 7.62) | |
| Women only | 3 | 17 | 3.87 (0.82, 18.22) | 10 | 4.29 (1.05, 17.53) | |
| <60 y | 7 | 30 | 1.76 (0.67, 4.61) | 11 | 2.15 (0.76, 6.10) | |
| ≥60 y | 8 | 33 | 5.24 (1.96, 14.01) | 31 | 4.32 (1.75, 10.67) | |
| Prostate | All | 42 | 56 | 1.64 (1.10, 2.46) | 32 | 0.93 (0.59, 1.49) |
| <60 y | 5 | 15 | 2.49 (0.90, 6.88) | 5 | 1.58 (0.44, 5.59) | |
| ≥60 y | 37 | 41 | 1.51 (0.97, 2.36) | 27 | 0.84 (0.51, 1.39) | |
| Lung | 33 | 27 | 1.14 (0.68, 1.90) | 16 | 0.69 (0.38, 1.25) | |
| Female breast | 20 | 24 | 1.13 (0.62, 2.06) | 16 | 1.24 (0.63, 2.45) | |
| Colorectal | 24 | 19 | 0.92 (0.50, 1.69) | 17 | 0.82 (0.43, 1.56) | |
| Bladder | 11 | 13 | 1.47 (0.65, 3.31) | 9 | 1.02 (0.42, 2.48) | |
| Non Hodgkin lymphoma | 7 | 6 | 1.08 (0.36, 3.26) | 9 | 1.59 (0.59, 4.31) | |
| Uterus | 11 | 5 | 0.42 (0.15, 1.23) | 4 | 0.63 (0.19, 2.07) | |
Hazard ratios refer to NMSC status (vs controls), adjusted for age at reference date, sex and smoking.
1
The melanoma models for BCC are adjusted for age at reference date, sex, smoking, skin reaction to chronic sun exposure and family history of NMSC.
2
The melanoma models for SCC are adjusted for age at reference date, sex, smoking, skin reaction to chronic sun exposure.
Stratified models are similarly adjusted except for the stratification variable.