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. 2014 Jun 10;8:745–757. doi: 10.2147/DDDT.S62659

Figure 8.

Figure 8

Map and Dex eye drops, administered 2 hours after antigen challenge, reduce conjunctival CCL5 (A), CCL11 (B), IL-1β (C), IL-8 (D), and TNF-α (E) mRNA levels in guinea pigs sacrificed 24 hours after OVA challenge.

Notes: Ctrls received the vehicle alone and were not treated with topical OVA. mRNA levels were measured by real time polymerase chain reaction using GAPDH as internal control. Values are the mean ± standard error of the mean (n=10; samples of both eyes of five guinea pigs were assayed). *P<0.05; §P<0.01 versus OVA + vehicle; #P<0.01 versus Ctrl (one-way ANOVA with Newman-Keuls post test).

Abbreviations: CCL5, chemokine C-C motif ligand 5; CCL11, chemokine C-C motif ligand 11; Ctrl, control; Dex, dexamethasone; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; IL-1β, interleukin-1β; IL-8, interleukin-8; Map, mapracorat; OVA, ovalbumin; TNF-α, tumor necrosis factor-α.