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. 2014 Jun 10;8:745–757. doi: 10.2147/DDDT.S62659

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© 2014 Baiula et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Map and Dex eye drops, administered 2 hours after antigen challenge, reduce conjunctival CCL5 and CCL11 protein levels in guinea pigs sacrificed 24 hours after OVA challenge.

Notes: Ctrls received the vehicle alone and were not treated with topical OVA. (A and B) Representative conjunctival samples showing, respectively, the detection of CCL5 and CCL11 by immunohistochemistry. (C and D) Immunohistochemical scores were assigned according to five categories (0: no staining; 1: 25% staining; 2: 25%–50% staining: 3, 50%–75% staining; and 4: >75% staining). Median values ± standard error of the mean are reported (n=10; samples of both eyes of five guinea pigs/group were assayed). *P<0.05; ^§P<0.01 versus OVA + vehicle; ^#P<0.01 versus Ctrl (Dunn’s post hoc test after Kruskal–Wallis).

Abbreviations: CCL5, chemokine C-C motif ligand 5; CCL11, chemokine C-C motif ligand 11; Ctrl, control; Dex, dexamethasone; IHC, immunohistochemistry; Map, mapracorat; OVA, ovalbumin.