Table I.
Variable | Without nicotinamide or MTH | With nicotinamide | With MTH |
---|---|---|---|
Plating efficiency (%) | |||
Without bevacizumab | |||
Without 10B-carrier | 84.4±8.2 | 81.4±7.3 | 83.5±8.7 |
With BPAc | 76.9±7.7 | 69.9±6.5 | 73.9±7.3 |
With BSHd | 81.4±8.3 | 74.9±6.3 | 78.9±6.8 |
With bevacizumab | |||
Without 10B-carrier | 80.1±8.0 | 76.3±7.1 | 78.4±8.3 |
With BPA | 69.6±7.1 | 64.8±6.2 | 68.8±7.0 |
With BSH | 74.1±7.7 | 69.8±7.2 | 73.8±7.1 |
Micronucleus frequency | |||
Without bevacizumab | |||
Total cell population | |||
Without 10B-carrier | 0.050±0.008 | 0.057±0.006 | 0.054±0.005 |
With BPA | 0.063±0.008 | 0.081±0.008 | 0.077±0.007 |
With BSH | 0.059±0.008 | 0.078±0.009 | 0.074±0.008 |
Quiescent cell population | |||
Without 10B-carrier | 0.077±0.008 | 0.084±0.009 | 0.081±0.009 |
With BPA | 0.091±0.009 | 0.110±0.011 | 0.105±0.010 |
With BSH | 0.095±0.009 | 0.120±0.011 | 0.115±0.011 |
With bevacizumab | |||
Total cell population | |||
Without 10B-carrier | 0.058±0.008 | 0.068±0.007 | 0.069±0.007 |
With BPA | 0.071±0.008 | 0.092±0.009 | 0.092±0.009 |
With BSH | 0.067±0.008 | 0.089±0.009 | 0.089±0.009 |
Quiescent cell population | |||
Without 10B-carrier | 0.083±0.008 | 0.086±0.009 | 0.087±0.009 |
With BPA | 0.097±0.009 | 0.112±0.011 | 0.111±0.011 |
With BSH | 0.101±0.009 | 0.122±0.011 | 0.121±0.011 |
Data are presented as mean ± standard error (n=9). MTH, mild temperature hyperthermia; BPA, l-para-boronophenylalanine-10B; BSH, sodium mercaptoundecahydrododecaborate-10B.