Table IV.
Enhancement ratiosa due to combined treatment with bevacizumab.
Variable | Without nicotinamide or MTH | With nicotinamide | With MTH |
---|---|---|---|
Surviving fraction = 0.3 | |||
Total cell population | |||
Without 10B-carrier | 1.25±0.1 | 1.05±0.1 | 1.3±0.1 |
With BPA | 1.55±0.2 | 1.05±0.1 | 1.7±0.15 |
With BSH | 1.35±0.1 | 1.05±0.15 | 1.35±0.15 |
Net micronucleus frequency = 0.3 | |||
Total cell population | |||
Without 10B-carrier | 1.1±0.1 | 1.05±0.1 | 1.2±0.1 |
With BPA | 1.2±0.2 | 1.05±0.1 | 1.3±0.15 |
With BSH | 1.15±0.1 | 1.05±0.1 | 1.25±0.15 |
Quiesent cell population | |||
Without 10B-carrier | 1.05±0.1 | 1.05±0.1 | 1.05±0.1 |
With BPA | 1.05±0.2 | 1.05±0.1 | 1.1±0.1 |
With BSH | 1.1±0.1 | 1.05±0.1 | 1.2±0.1 |
Data are presented as mean ± standard error (n=9).
Ratio of the dose of radiation necessary to obtain each end-point without bevacizumab to that needed to obtain each end-point with bevacizumab;
MTH, mild temperature hyperthermia; BPA, L-para-boronophenylalanine-10B; BSH, sodium mercaptoundecahydrododecaborate-10B.