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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Pigment Cell Melanoma Res. 2014 Apr 11;27(4):621–629. doi: 10.1111/pcmr.12237

Figure 3. Functional IGF-1R is required for mGluR1-mediated tumorigenicity.

Figure 3

(A) Expression of c-Myc-tagged truncated IGF-1R mutant in IGF-RDN-MASS20 clones was visualized by immunoblotting for c-Myc tag. (B) Activation of AKT in IGF-1 treated parental MASS20 cells. Truncated IGF-1R mutant in MASS20 cells inhibits IGF-1(5ng/ml)-induced AKT activation (bottom panel). (C) One vector control and two different IGF-1RDN-MASS20 clones were inoculated into immunodeficient nude mice. Approximately, 35% reduction of tumor volumes in IGF-1RDN-MASS20 clones as compared to Vector-MASS20.