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Roles of Wnt5a in cancer metastasis- (A) promoting and (B) suppressive processes. Fzd, frizzled; PI3K, phosphatidylinositol 3-kinase; PKC, protein kinase C; AKT, protein kinase B; JNK, c-Jun N-terminal kinase; ARF-6, ADP-ribosylation factor 6; IL-10, interleukin-10; CAMKII, Ca2+/calmodulin-dependent protein kinase II; TLR4, Toll-like receptor 4; NFκB, nuclear factor κB; ROR2, receptor tyrosine kinase-like orphan receptor 2.
