Table 4.
Multivariable Logistic Regression Results Predicting Early Nonpersistence to Antihypertensive Agents Among Patients With a History of Depression
| Class | Proportion Nonpersistent | Odds Ratios (95% CI) |
|---|---|---|
| Race | ||
| White | 36.3 | |
| Black | 50.5 | 1.65 (1.02–2.66) |
| Asian | 46.5 | 1.42 (0.89–2.27) |
| Hispanic | 39.4 | 0.97 (0.66–1.41) |
| Other/missing | 36.5 | 1.07 (0.81–1.42) |
| Age, y | ||
| <50 | 43.8 | |
| 50–64 | 33.1 | 0.65 (0.51–0.84) |
| 65–74 | 34.4 | 0.62 (0.39–0.98) |
| 75+ | 41.9 | 0.82 (0.45–1.49) |
| Sex | ||
| Male | 37.4 | |
| Female | 39 | 1.04 (0.81–1.32) |
| Smoker | ||
| No | 38.2 | |
| Yes | 39.1 | 1.02 (0.75–1.39) |
| BMI | ||
| <24.99 (normal) | 42.5 | |
| 25–29.99 (overweight) | 39.4 | 0.91 (0.64–1.29) |
| ≥30 (obese) | 38.5 | 0.85 (0.61–1.19) |
| Missing | 26.4 | 0.72 (0.38–1.38) |
| Baseline SBP, mm Hg | ||
| <140 | 38.6 | |
| 140–149 | 39.6 | 1.05 (0.79–1.40) |
| 150–159 | 36.2 | 0.94 (0.68–1.31) |
| 160+ | 42.8 | 1.22 (0.84–1.77) |
| Household income, $ | ||
| <40,000 | 39.9 | |
| 40,000–74,999 | 37.8 | 0.97 (0.72–1.31) |
| ≥75,000 | 38.5 | 1.01 (0.71–1.43) |
| Copay, $ | ||
| <6 | 36.9 | |
| 6–10 | 38.9 | 1.10 (0.85–1.42) |
| 11+ | 38.5 | 1.15 (0.74–1.77) |
| Comorbidity | ||
| Diabetes | 39.1 | 1.01 (0.65–1.57) |
| CKD | 39.4 | 0.88 (0.37–2.08) |
| Prior CVD | 46.3 | 1.84 (0.92–3.67) |
| Ever schizophrenia | 25 | 0.25 (0.03–2.20) |
| Ever bipolar disorder | 29.6 | 0.64 (0.26–1.61) |
| Ever anxiety | 42.3 | 1.11 (0.80–1.52) |
| Total visits | ||
| 0 | 25.5 | |
| 1 or 2 | 35.4 | 1.08 (0.57–2.05) |
| 3 to 5 | 40.3 | 1.20 (0.63–2.31) |
| 6 to 15 | 42.5 | 1.27 (0.65–2.50) |
| Antidepressant use | ||
| No antidepressant use | 43 | |
| Not persistent for 6 mo | 42.8 | 0.92 (0.61–1.37) |
| Persistent for 6 mo | 32.1 | 0.64 (0.42–0.96)b |
Abbreviations: BMI, body mass index; CI, confidence interval; CKD, chronic kidney disease; CVD, cardiovascular disease; SBP, systolic blood pressure. a P≤.05. b P≤.01.