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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Curr Opin Cell Biol. 2014 Mar 22;0:46–53. doi: 10.1016/j.ceb.2014.02.001

Figure 2.

Figure 2

Structural features of the nuclear periphery. A. Shown is an electron micrograph of the nuclear periphery of a HeLa cell. Densely staining heterochromatin is visible adjacent to nucleoplasmic face of the inner nuclear membrane (INM). The continuity of the peripheral heterochromatin is interrupted by lesser straining euchromatin channels at positions along the NE occupied by NPCs. B. A cartoon of the interplay between chromatin and the nuclear periphery is shown. Heterochromatin associates with the INM, but is excluded from regions containing NPCs in a manner dependent upon the nuclear basket. These regions of heterochromatin exclusion contain transcriptionally active euchromatin. ONM - outer nuclear membrane