Table 2.

Multivariable analysis of maternal and fetal outcomes in subjects with history of one or multiple SABs.

Outcome	Primigravid (N=7681)	One SAB (N=1060)	Two or More SABs (N=180)
Spontaneous preterm birth*	438 (5.8)	58 (5.6) 1.0 [0.7–1.3]	25 (14.4) 2.6 [1.7–4.0]
Indicated preterm birth*	231 (3.0)	35 (3.4) 1.1 [0.7–1.5]	6 (3.4) 1.0 [0.4–2.4]
Preterm PROM	172 (2.3)	23 (2.2) 0.9 [0.6–1.4]	13 (7.3) 2.9 [1.6–5.3]
Pre-eclampsia	539 (7.0)	74 (7.0) 1.0 [0.7–1.2]	9 (5.0) 0.6 [0.3–1.2]
Fetal/Neonatal death	157 (2.1)	35 (3.3) 1.5 [1.1–2.3]	12 (6.7) 2.8 [1.5–5.3]
Birthweight < 5th percentile	371 (4.9)	48 (4.7) 1.0 [0.7–1.3]	17 (9.9) 2.2 [1.3–3.7]
Neonatal intensive care admission	861 (11.2)	110 (10.4) 0.9 [0.7–1.1]	27 (15.1) 1.2 [0.8–1.8]

Data shown are number of outcomes (percent)

Odds ratio compared to the primigravid group [95% confidence interval] were calculated after adjusting for maternal age, race, education, smoking, marital status, BMI at enrollment, and study drug (placebo or vitamin C and E). Odds ratio in bold typeface are statistically significant.

SAB=spontaneous abortion, PROM=premature rupture of membranes

^*Excludes 110 women whose current pregnancy resulted in SAB or IAB (87 primigravid, 17 one SAB, 6 two or more SABs).