Table 2.
Outcome | Primigravid (N=7681) | One SAB (N=1060) | Two or More SABs (N=180) |
---|---|---|---|
Spontaneous preterm birth* | 438 (5.8) | 58 (5.6) 1.0 [0.7–1.3] |
25 (14.4) 2.6 [1.7–4.0] |
Indicated preterm birth* | 231 (3.0) | 35 (3.4) 1.1 [0.7–1.5] |
6 (3.4) 1.0 [0.4–2.4] |
Preterm PROM | 172 (2.3) | 23 (2.2) 0.9 [0.6–1.4] |
13 (7.3) 2.9 [1.6–5.3] |
Pre-eclampsia | 539 (7.0) | 74 (7.0) 1.0 [0.7–1.2] |
9 (5.0) 0.6 [0.3–1.2] |
Fetal/Neonatal death | 157 (2.1) |
35 (3.3) 1.5 [1.1–2.3] |
12 (6.7) 2.8 [1.5–5.3] |
Birthweight < 5th percentile | 371 (4.9) | 48 (4.7) 1.0 [0.7–1.3] |
17 (9.9) 2.2 [1.3–3.7] |
Neonatal intensive care admission | 861 (11.2) | 110 (10.4) 0.9 [0.7–1.1] |
27 (15.1) 1.2 [0.8–1.8] |
Data shown are number of outcomes (percent)
Odds ratio compared to the primigravid group [95% confidence interval] were calculated after adjusting for maternal age, race, education, smoking, marital status, BMI at enrollment, and study drug (placebo or vitamin C and E). Odds ratio in bold typeface are statistically significant.
SAB=spontaneous abortion, PROM=premature rupture of membranes
Excludes 110 women whose current pregnancy resulted in SAB or IAB (87 primigravid, 17 one SAB, 6 two or more SABs).