Table 4.
Outcome | Less than 6 months (N=395) | 6–12 months (N=216) | Greater than 12 months (N=429) |
---|---|---|---|
Spontaneous preterm birth* | 17 (4.4) | 15 (7.0) 1.6 [0.8–3.4] |
24 (5.7) 1.2 [0.6–2.3] |
Indicated preterm birth* | 14 (3.6) | 4 (1.9) 0.5 [0.2–1.5] |
17 (4.0) 0.9 [0.4–2.0] |
Preterm PROM | 6 (1.5) |
11 (5.2) 3.7 [1.3–10.3] |
5 (1.2) 0.8 [0.2–2.8] |
Pre-eclampsia | 31 (7.8) | 11 (5.1) 0.6 [0.3–1.2] |
31 (7.2) 0.8 [0.4–1.3] |
Fetal/Neonatal death | 13 (3.3) | 6 (2.8) 0.7 [0.3–2.0] |
16 (3.8) 0.8 [0.3–1.7] |
Birthweight < 5th percentile | 20 (5.2) | 6 (2.8) 0.5 [0.2–1.2] |
22 (5.3) 0.9 [0.5–1.7] |
Neonatal intensive care admission | 43 (10.9) | 16 (7.5) 0.6 [0.3–1.1] |
50 (11.7) 0.9 [0.6–1.4] |
Data shown are number of outcomes (percent)
Odds ratio compared to the less than 6 months group [95% confidence interval] were calculated after adjusting for maternal age, race, education, smoking, marital status, BMI at enrollment, and study drug (placebo or vitamin C and E). Odds ratio in bold typeface are statistically significant.
SAB=spontaneous abortion, PROM=premature rupture of membranes
Excludes 17 women whose current pregnancy resulted in SAB or IAB.