Table 4.

Multivariable analysis of maternal and fetal outcomes in subjects with history of one SAB based on inter-pregnancy interval.

Outcome	Less than 6 months (N=395)	6–12 months (N=216)	Greater than 12 months (N=429)
Spontaneous preterm birth*	17 (4.4)	15 (7.0) 1.6 [0.8–3.4]	24 (5.7) 1.2 [0.6–2.3]
Indicated preterm birth*	14 (3.6)	4 (1.9) 0.5 [0.2–1.5]	17 (4.0) 0.9 [0.4–2.0]
Preterm PROM	6 (1.5)	11 (5.2) 3.7 [1.3–10.3]	5 (1.2) 0.8 [0.2–2.8]
Pre-eclampsia	31 (7.8)	11 (5.1) 0.6 [0.3–1.2]	31 (7.2) 0.8 [0.4–1.3]
Fetal/Neonatal death	13 (3.3)	6 (2.8) 0.7 [0.3–2.0]	16 (3.8) 0.8 [0.3–1.7]
Birthweight < 5th percentile	20 (5.2)	6 (2.8) 0.5 [0.2–1.2]	22 (5.3) 0.9 [0.5–1.7]
Neonatal intensive care admission	43 (10.9)	16 (7.5) 0.6 [0.3–1.1]	50 (11.7) 0.9 [0.6–1.4]

Data shown are number of outcomes (percent)

Odds ratio compared to the less than 6 months group [95% confidence interval] were calculated after adjusting for maternal age, race, education, smoking, marital status, BMI at enrollment, and study drug (placebo or vitamin C and E). Odds ratio in bold typeface are statistically significant.

SAB=spontaneous abortion, PROM=premature rupture of membranes

^*Excludes 17 women whose current pregnancy resulted in SAB or IAB.