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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2013 Nov 12;144PA:237–241. doi: 10.1016/j.jsbmb.2013.11.002

Fig. 4. A reciprocal role of 1,25(OH)2D3/VDR in β-catenin/TCF target genes.

Fig. 4

A model to show 1,25(OH)2D3/VDR repression of β-catenin/TCF stimulation of genes involved with proliferation as VDR and TCF/LEF proteins compete for β-catenin binding (upper panel). In contrast, VDR activates β-catenin to promote keratinocyte differentiation by promoting β-catenin binding to the TCF/LEF response elements in genes with adjacent VDREs that mediate differentiation (lower panel).