Figure 2.

Repeated AMPH treatment alters mesocorticolimbic OTR and DA D2R immunoreactivity in female prairie voles. A, Schematic drawing illustrating tissue punch locations in the mPFC, NAcc, and VTA. B, OTR-ir was significantly lower in the mPFC of AMPH-treated, than EB-treated control, females. No group differences were noted in OTR-ir in the NAcc or VTA. C, D2R-ir was significantly lower in the NAcc, but not in the mPFC or VTA, of AMPH-treated, compared with EB-treated control, females. Error bars indicate the SEM. *p ≤ 0.017.