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. 2014 Jun 10;15(1):455. doi: 10.1186/1471-2164-15-455

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© Zeng et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Distribution of NAS of the first sequence in each block. Shown are the general distribution of NAS (boxplot) and those from two proteins, IL10RA (dashed line) and GNAS (intermittent dashed line). The general distribution of NAS of the first sequences from each block was generated from randomly selected 12,000 human proteins in UniProt. IL10RA, which encodes a subunit of the interleukin-10 receptor, and GNAS (Guanine nucleotide-binding protein G(s) subunit alpha isoform short), a house-keeping signal transduction molecule, are presented here as examples of different evolving rates of proteins.