Table 1. Association of protein-coding genes, can-lncRNAs and eRNAs with NFκB binding.
Gene set | Observed | Expected | Fold Enrichment | P -value | Q -value |
---|---|---|---|---|---|
Protein coding | 188,011 | 66,434.98 | 2.83 | 1 × 10−4 | 1.6 × 10−4 |
can-lncRNA | 11,482 | 2,764.43 | 4.15 | 1 × 10−4 | 8 × 10−4 |
eRNA | 7,090 | 5,076.86 | 1.40 | 0.16 | 0.21 |
can-lncRNA (gene body) | 42,150 | 6,854.14 | 6.15 | 1 × 10−4 | 3.4 × 10−4 |
eRNA (gene body) | 39,645 | 6,260.16 | 6.33 | 1 × 10−4 | 3.4 × 10−4 |
Empirical P-values for associations of the respective gene sets with NF-κB binding intervals were calculated using 10,000 randomizations in a simulation procedure implemented using the Genomic Association Tester (GAT). GAT derived Q-values, used to control for the number of gene sets analysed, are also provided.