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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Hypertension. 2014 May 5;64(1):178–184. doi: 10.1161/HYPERTENSIONAHA.114.03335

Figure 8. Model of NE effects on SPAK and OxSR1 in the DCT.

Figure 8

Cartoon shows effects of NE on SPAK (left panels) and OxSR1 (middle panels) distribution in wild type mice. Note that OxSR1, but not SPAK, shifts to an apical location. The right panels show effects of NE on OxSR1 in SPAK knockout mice. Notice that SPAK knockout causes OxSR1 to shift to a more punctate appearance. Upon NE stimulation, OxSR1 shifts substantially toward the apical membrane. The NCC is phosphorylated (P), upon activation.