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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Anesthesiology. 2014 Jul;121(1):149–159. doi: 10.1097/ALN.0000000000000285

Figure 6.

Figure 6

Effect of (R,S)-norketamine on the levels of phospho-active forms of mTOR, Akt, ERK1/2, p70S6K and 4E-BP1 in PC-12 cells. A, Cells were treated with different concentrations of (R,S)-norketamine (0 – 1 μM) for 1 h and processed for Western blot analysis. (B), Scatter plots illustrating the relative ratio of phosphorylated versus total forms of mTOR, Akt, ERK1/2, p70S6K and 4E-BP1 in response to cell treatment with 25 nM of (R,S)-norketamine are shown (n = 3 independent experiments). *, ** P< 0.05, 0.01 (ANOVA) compared with control cells.