Mean (± SEM) Trial 2 latency to immobility, total immobility, swimming, climbing and diving in male rats in response to creatine and/or 5.0 mg/kg fluoxetine (Experiment 1; 3a-e) and 10.0 mg/kg fluoxetine (Experiment 2; 3f-j) as a function of creatine supplementation. Means with different letters are statistically significant (p < 0.05). In Experiment 1, 5.0 mg/kg fluoxetine had no effect on latency to the onset of immobility, mean counts of immobility, swimming, or climbing when administered alone or when combined with creatine (a-e). In Experiment 2, there were no interaction effects of creatine and 10.0 mg/kg fluoxetine on any forced swim behaviors (3f-j).