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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Mol Biosyst. 2014 Jan;10(1):9–17. doi: 10.1039/c3mb70225a

Fig. 2.

Fig. 2

Schematic representations of high-throughput assays used to generate binary interactome networks. (A) Yeast two-hybrid (Y2H). (B) Protein fragment complementation assays (PCA). (C) Luminescence-based mammalian interactome mapping (LUMIER). (D) Well-based nucleic acid programmable protein array (wNAPPA). (E) Mammalian protein–protein interaction trap (MAPPIT). (F) A high-quality reference human binary interactome comprising B40 000 interactions generated from several large-scale interactome mapping efforts and thousands of small-scale studies.