Fig. 3.

Structurally resolved interactome networks and human disease. (A) Construction of a structurally resolved interactome network onto which disease mutations are mapped. (B) Percentage of mutation pairs on two proteins that cause the same disease. (C) Percentage of mutation pairs on the same protein that cause different diseases. (D) A higher resolution of the guilt-by-association principle – mutations at different structural loci on the same protein that cause different diseases [(B) and (C) are adapted from ref. 54].