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. Author manuscript; available in PMC: 2015 Apr 15.
Published in final edited form as: Cancer Res. 2014 Mar 3;74(8):2171–2181. doi: 10.1158/0008-5472.CAN-13-0094

Figure 3. T cell-derived TSP-1 is necessary to suppress tumor growth by inhibition of angiogenesis after immune activation.

Figure 3

Host TSP-1 is dispensable for tumor inhibition. BM transplants were performed with A, B) WT or C) Tsp1−/− donors into Tsp1−/− or WT hosts, as indicated. After reconstitution, mice were injected with B16F10 cells then infected with either LCMVa or RPMI control when tumors were measurable. Graphs represent tumor volume. * p< 0.05. n ≥ 5 mice per group. D) WT or E) Tsp1−/− T cells were transferred into Rag1−/− mice. Mice were injected with B16F10 cells and infected with either LCMVa or RPMI control when tumors were measurable. Graphs indicate tumor volumes at indicated days after infection. * p< 0.05. n = 7 mice per group.