Table 4.

Top protein biomarkers of atherosclerotic cardiovascular disease: results of single marker analyses from MRM and depletion MRM mass spectrometry

Gene Symbol	Protein Name	Paired t test		Conditional Logistic Regression
		Mean difference (case-control) ± s.e.	P value	Odds Ratio (95% CI)	P value
MRM (n=336 pairs)
ORM1	Alpha-1-acid glycoprotein 1	0.29±0.07	<0.0001	1.43(1.16,1.76)	0.0007
CRP	C-reactive protein	0.35±0.07	<0.0001	1.38(1.13,1.69)	0.0016
CP	Ceruloplasmin	0.15±0.06	0.023	1.37(1.11,1.70)	0.0037
SAA1	Serum amyloid A-1 protein	0.27±0.07	0.0003	1.30(1.08,1.57)	0.0065
GSN	Gelsolin	−0.30±0.07	<0.0001	0.77(0.62,0.95)	0.013
CLEC3B	Tetranectin	−0.30±0.07	<0.0001	0.76(0.62,0.95)	0.015
HPX	Hemopexin	0.23±0.07	0.0007	1.26(1.03,1.55)	0.024
PON1	Paraoxonase 1	−0.16±0.07	0.017	0.79(0.64,0.98)	0.031
SERPINA10	Protein Z-dependent protease inhibitor	0.20±0.07	0.0031	1.25(1.01,1.53)	0.037
LRG1	Leucine-rich alpha-2-glycoprotein	0.09±0.07	0.17	1.24(1.01,1.52)	0.039
Depletion MRM (n=336 pairs)
SERPINA10	Protein Z-dependent protease inhibitor	0.20±0.08	0.0070	1.21(1.01,1.46)	0.036
NCAM1	Neural cell adhesion molecule 1	−0.19±0.07	0.0067	0.82(0.68,1.00)	0.048

This table shows markers with p-value <0.05 in conditional logistic regression (n=336 pairs). For each biomarker, data were rank normalized and have mean 0, SD 1. Differences, standard errors and odds ratios are in unit of one standard deviation.

Conditional logistic regression results are adjusted for age, sex, current smoking status, statin use, systolic blood pressure, hypertension treatment status, total cholesterol, HDL cholesterol, diabetes status and BMI. Results are sorted by CLR values.