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Schematic of 10MDR, one of the 10-base nucleic acid hybrids used in this study. Ten bases of DNA-RNA hybrid extend from the base of the loop to the 5′ and 3′ ends of the oligonucleotide. Four thymidines, that remain single-stranded, form the hairpin loop. Other hybrids are similar in design, but differ in hybrid length, in percent GC content, and whether they are DNA-DNA, RNA-RNA, or DNA-RNA.
