Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model of the interactions between extracellular histones and the NLRP3 inflammasome during ALI. 1) Neutrophils are the source of extracellular histones during ALI (Fig. 3 and 4). 2) Extracellular histones activate the NLRP3 inflammasome (Fig. 5). 3) The NLRP3 inflammasome is required for optimal neutrophil influx (Fig. 1D) and histone presence (Fig. 8).
