Figure 9.
Evidence that histone/inflammasome-mediated inflammation is conserved among ALI models. A) Albumin, histone, and IL-1β levels observed in BALF 6 hours after the i.t. instillation of C5a (500 ng). Sham animals received sterile PBS (n=4 mice per group). B) Albumin, histone, and IL-1β levels found in BALF 6 hours after the distal airway deposition of IgG immune complexes. Sham animals received only anti-BSA (n=5 mice per group).