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. 2012 Oct 31;2(4):573–588. doi: 10.3390/brainsci2040573

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© 2012 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Effects of Intra-NAcc or Intra-VTA Sulpiride on Reinstatement. (A) Adult rats with a history of early cocaine exposure showed cocaine induced reinstatement of cocaine place conditioning (grey bars; indicated by *). There was no effect of intra-NAcc sulpiride on cocaine-induced reinstatement of cocaine place conditioning (grey striped bars; indicated by *). Sample sizes = 8 sal/sal; 7 sal/sul; 8 coc/sal; 8 coc/sul. (B) Adult rats with a history of early cocaine exposure showed cocaine induced reinstatement of cocaine place conditioning (grey bars; indicated by ^#). Intra-VTA sulpiride blocked cocaine-induced reinstatement of cocaine place conditioning (grey striped bars). Sample sizes = 8 sal/sal; 8 sal/sul; 8 coc/sal; 8 coc/sul. NAcc = nucleus accumbens, VTA = ventral tegmental area, sal = saline, sul = sulpiride and coc = cocaine. All bars denote means and SEM.