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Experimental design.
| Age (Postnatal day, PND) | 30–39 | 40 | 65 | 70 |
|---|---|---|---|---|
| Phase | Conditioned place preference (CPP) | Extinction | Surgery | Reinstatement |
| saline | NAcc | saline | ||
| saline | NAcc | sulpiride | ||
| cocaine | NAcc | saline | ||
| cocaine | NAcc | sulpiride | ||
| saline | VTA | saline | ||
| saline | VTA | sulpiride | ||
| cocaine | VTA | saline | ||
| cocaine | VTA | sulpiride |
