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. 2013 Jul 22;3(3):1109–1127. doi: 10.3390/brainsci3031109

Figure 1.

Figure 1

Widespread astrogliosis is a prominent neuropathological feature of the twitcher mouse brain. Representative pictures show immunohistochemically labeled glial fibrillary acidic protein (GFAP)+ astrocytes (red) in several regions of the brain, including cerebellum, midbrain, thalamus, and cortex in wildtype C57BL/6 (upper row) and in age-matched twitcher mice (bottom row). Note that highly fibrous GFAP immunoreactivity is observed with greater intensity throughout the twitcher mouse brain, compared to wildtype mouse. Scare bar = 250 μm.