Effect of perinatal ethanol exposure on dam weight gain during pregnancy and litter size. There were no significant differences in weight gain over pregnancy between perinatal conditions. 1st trimester pair-fed animals had significantly more pups than 1st trimester ethanol exposed animals, but all other groups had comparable litter sizes. Results are expressed as means ± standard error of the mean (SEM). Results are considered statistically significant if p < 0.05. * p < 0.05, as compared to 1st trimester ethanol exposed dams.