Table 1.

Biochemical and morphometric data

	Treatment alone			BADGE co-treatment
Variable	Control ASO	Trib3 ASO	Significance	Control ASO	Trib3 ASO	Significance
Body weight (g)	357.9±8	349.4±6		361.4±6	355±12
White adipose tissue (g)	3.0±0.2	5.2±0.4	**	4.0±0.3	4.0±0.4
Leptin (µg/l)	1.6±0.2	2.7±0.6		1.8±0.4	1.9±0.3
Adiponectin (mg/l)	2.4±0.2	2.9±0.1	*	2±0.3	2.4±0.8
IL-6 (ng/l)	35.9±9	23.3±9		161±56	260±63
TNF α (ng/l)	2.9±0.6	2.7±0.3		7.7±2	16±5
Insulin (pmol/l)	111±28	118±35		250±21	118±21	***
Glucagon (ng/l)	47.6±3	53±6		ND	ND
Glucose (mmol/l)	6.9±0.1	7.4±0.3		5.7±0.2	5.9±0.2
ALT (U/l)	44±6	57±9		ND	ND
AST (U/l)	146±28	192±33		ND	ND
Cholesterol (mmol/l)	1.5±0.1	2.13±0.2	*	1.5±0.1	2±0.2
HDL (mmol/l)	0.6±0.05	0.9±0.1	*	0.5±0.05	0.7±0.05	0.05
NEFA (mEq/l)	0.7±0.04	0.8±0.07		0.45±0.07	0.4±0.05
NEFA suppression (mEq/l)	−0.45±0.05	−0.69±0.06	*	ND	ND
Plasma triacylglycerol (mmol/l)	0.28±0.03	0.31±0.02		0.6±0.03	0.6±0.7

Data are presented as mean±SEM

^*p<0.05,

^**p<0.01 and

^***p<0.001 compared with control ASO

ALT, alanine transferase; AST, aspartate transferase; mEq, milliequivalent; ND, not determined