Table 2.
IC:50s at 72 h of different UTR agonists and antagonists on bladder cancer cell lines
|
Cell lines |
Compounds IC:50 (nM) |
||||
|---|---|---|---|---|---|
| UII | Urantide | UPG83 | UPG85 | UPG84 | |
|
T24 |
n.d. |
350 ± 8 |
n.d. |
n.d. |
7 ± 0,6 |
|
RT112 |
n.d. |
375 ± 6 |
n.d. |
n.d. |
n.d. |
|
MCR |
n.d. |
n.d |
n.d. |
n.d. |
9,8 ± 0,5 |
| HT1376 | n.d. | n.d. | 1000 ± 9 | n.d. | 7,9 ± 0,4 |
n.d.: not detectable; IC:50: drug concentration that induces the 50% of cell growth inhibition after 72 h from the beginning of the treatment; UII: urotensin II.