Figure 4.

Segregation of KIR2DL5 in five Gambian families. Patterns of segregation are consistent with Mendelian inheritance and with segregation of the linked KIR2DS3 and KIR2DS5 genes. In most world populations, KIR2DL5 is in perfect linkage disequilibrium with KIR2DS3 and KIR2DS5. In Gambia, these genes are in almost perfect linkage disequilibrium (Roberts C.h., Molina, S., Makalo, P., Joof, H., Harding-Esch, E.M., Burr, S.E., Mabey, D.W., Bailey, R.L., Burton, M.J. and Holland, M.J., in press). The absence of both KIR2DS3 and KIR2DS5 implies that KIR2DL5 will be absent. The presence of both genes indicates that at least two KIR2DL5 copies are present. The co-segregation of KIR2DL5 with the KIR2DS3 and KIR2DS5 genes is expected and was observed in these pedigrees. To protect the anonymity of participant families, all F₁ subjects have been changed to ‘male’.