Figure 4.

Mutation signatures in lung adenocarcinoma. (a-d) Four signatures that are prominent in lung adenocarcinoma [8]. The x axes are organized as in Figure 3 c. However, unlike in Figure 3c, the y axes in these plots represent proportions of mutations in inferred rather than observed signatures. (a) Signature of APOBEC-induced mutagenesis. (b) 'Age 1B', one of two signatures that correlated with age. (c) Tobacco smoke. (d) 'Signature 5' from [8], due to an unknown exposure or mutational process. (e) Almost all lung adenocarcinomas have mutations that are overlays of several of the signatures above. Signature R2 is an additional signature that may partly represent sequencing errors [8]. All panels adapted from [8] with permission from Macmillan Publishers Ltd.