Table 2.

Validated hits

Drug	Gene name	Accession number	Description	Number of validated/tested candidate genes
Methotrexate	DHFR	BC000192	Dihydrofolate reductase	1/3
Aminopterin	DHFR	BC000192	Dihydrofolate reductase	1/9
Bleomycin	IMMT	BC002412	Inner membrane protein, mitochondrial (mitofilin)	2/30
	STX3	BC007405	Syntaxin 3
Cisplatin	MAP2K1IP1	BC026245	Mitogen-activated protein kinase kinase 1 interacting protein 1	4/15
	MMD	BC026324	Monocyte to macrophage differentiation-associated
	PTPN2	BC016727	Protein tyrosine phosphatase, non-receptor type 2
	RHOXF2	BC021719	Rhox homeobox family, member 2
Mitomycin C	C20orf54	BC009750	Chromosome 20 open reading frame 54	8/19
	CCDC45	BC009518	Coiled-coil domain containing 45
	ELF5	BC029743	E74-like factor 5 (ets domain transcription factor)
	PTPN2	BC008244	Protein tyrosine phosphatase, non-receptor type 2
	RHOXF2	BC021719	Rhox homeobox family, member 2
	TMEM150	BC050466	Transmembrane protein 150
	USPL1	BC038103	Ubiquitin specific peptidase like 1
	ZFP64	BC012759	Zinc finger protein 64 homolog (mouse)
17-DMAG	EIF4B	BC073139	Eukaryotic translation initiation factor 4B	1/29
Orlistat	MGLL	BC006230	Monoglyceride lipase	2/18
	PON3	BC070374	Paraoxonase 3