Figure 14.

PXRD comparison (black trace) of (a) ACM–PABA and (b) ACM–PPZ salt after 24 h slurry with the calculated X-ray diffraction lines of the salt (red trace) and ACM hydrate (ACMH, blue). Both of these binary systems are relatively stable compared with the cocrystals, which transformed to ACMH in pH 7 buffer. There is a higher amorphous content in the recovered ACM–PPZ salt (halo + lines). The product stability in slurry medium was confirmed by FT–IR.