Table 8. Dissolution of acemetacin cocrystals/salts in pH 7 buffer medium at 37C.
| Absorption coefficient (, mM1cm1) | Solubility at 24h (gL1)† | IDR (mgcm2min1)† | Solubility (gL1) of the coformer | Residue after 4h in IDR | Residue after 24h slurry | |
|---|---|---|---|---|---|---|
| ACM | 7.71 | 3.2 (2.0) | 2.118 (3.4) | ACMH | ACMH | |
| ACMH | 6.49 | 1.6 | 0.618 | ACMH | ACMH | |
| ACMNAM | 5.93 | 22.0 (13.7) | 3.223 (5.2) | 800 | ACMNAM | ACMH |
| ACMINA | 7.06 | 21.0 (13.1) | 1.165 (1.8) | 192 | ACMINA | ACMH |
| ACMPAM | 6.78 | 17.2 (10.7) | 2.902 (4.7) | 180 | ACMPAM | ACMPAM, ACMH |
| ACMCPR | 7.15 | 20.5 (12.8) | 2.195 (3.5) | 4560 | ACMCPR | ACMH |
| ACMPABA | 6.77 | 21.6 (13.5) | 1.631 (2.6) | 7 | ACMPABA | ACMPABA |
| ACMPPZ | 6.78 | 26.8 (16.7) | 3.260 (5.3) | 150 | ACMPPZ | ACMPPZ |
†
Value in parenthesis is the enhancement multiple compared to the least soluble ACMH.