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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Exp Hematol. 2013 Oct 26;42(2):114–25.e4. doi: 10.1016/j.exphem.2013.10.004

Figure 1. Experimental design for screening candidate proto-oncogenes.

Figure 1

(A) Schematic overview of the experimental design used to test genes identified as common insertions sites for their influence on hematopoietic progenitor activity. (B) Results of the competitive repopulation assays. Shown is BM chimerism after 18 weeks normalized to the chimerism induced by HOXB4 expression. (C) Replanting frequency of transduced and sorted LSK cells in CFU assays. Five hundred cells per ml MethoCult were plated in all three rounds of replating (n=3).