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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Exp Hematol. 2013 Oct 26;42(2):114–25.e4. doi: 10.1016/j.exphem.2013.10.004

Figure 4. HOXC6 mice developed leukemia with an AML phenotype.

Figure 4

(A) White blood cell counts from GFP, HOXB4 and HOXC6 transplanted mice. (B) Blood smears from leukemic HOXC6 mice show increased white blood cell counts, left shifted myelopoiesis in the peripheral blood and cells with blast morphology (Hematoxylin-Eosin staining; x60). Spleen and bone marrow is overgrown with myeloid progenitor cells (Hematoxylin-Eosin staining; x40). (C) Flow cytometry analysis of the peripheral blood and bone marrow revealed that the cells of leukemic mice have an immature myeloid phenotype as indicated by high cKit expression. No phenotypic difference was detectable between cells from peripheral blood or bone marrow. (D) Survival of secondary transplants of mice from four different primary mice. One mouse with a myeloproliferative disorder diagnosed by histology (Number 4) showed evolution to leukemia in secondary transplant.