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. 2014 May 13;8:54. doi: 10.1186/1752-0509-8-54

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Copyright © 2014 Ouzounoglou et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Graphical representation of the model structure in SBGN for: (A) ASYN and DA production and (B) ASYN oligomerization and modification sub-models. (A) WT ASYN (WTasyn) and DA (Dopamine) are produced by SOURCE (see text for details). The WT ASYN is modified by DA to form the modified ASYN Monomer (DopModWTasyn). The DA species are degraded by a simple degradation reaction. (B) WT (WTasyn-WTasyn9) and DA-modified (DopModWTasyn-DopModWTasyn9) can form oligomers of higher order (black colored reactions) by the addition of a monomer. Moreover, oligomers could dissociate to oligomers of a lower order by freeing a monomer species (red colored reactions). Only WT ASYN species can form HMW species (HigherWTasynSPC).