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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Curr Rheumatol Rep. 2013 Aug;15(8):350. doi: 10.1007/s11926-013-0350-2

Table 2.

Murine Models of Spontaneous Osteoarthritis

KO/TG STRAIN OF
MICE		 MODEL TIME POINT TISSUES
STUDIED		 FINDINGS REF
aggrecan-knockin (Jaffa, ADAMTS resistant) C57BL/6 aging 12 months old cartilage, bone
  • -

    No change in cartilage

  • -

    No change in growth plates or skeletal morphology

 Little 2007
Adam15 ko (metargidin) 129/SvJ aging 3-, 6-, 12–14-months old cartilage, bone, synovium, meniscus, tendons, ligaments
  • -

    At 3 months, no change

  • -

    At 6 months, increased synovial hyperplasia

  • -

    At 12–14 months, significantly worse histological score compared to WT (score summed: proteoglycan loss, cartilage erosion, necrosis, osteophyte formation, synovial hyperplasia, mensici cartilage erosion, metaplasia in tendons/ligaments)

 Bohm 2005
Timp3 ko C57BL/6 aging 4 weeks to 24 months old cartilage, meniscus
  • -

    At 6 months, increased VDIPEN and slight increase in NVTEGE in articular cartilage and menisci

  • -

    At 6 months, increased pericellular collagenase activity

  • -

    At 6 months, increased collagen × expression throughout cartilage

  • -

    At 8 months, increased aggrecan degradation, no evidence fibrosis

 Sahebjam 2007
Mmp2 ko C57BL/6J aging up to 6 months old cartilage, bone
  • -

    KO mice display attenuated features of human multicentric osteolysis with arthritis (MOA) including progressive articular cartilage destruction, loss of bone mineral density, abnormal long bone and craniofacial development, and decreases in osteoblast and osteoclast numbers

 Mosig 2007
Mmp3 ko (Str1) ko B10.RIII aging 1, 2 years old cartilage, bone, synovium
  • -

    At 1 year, only mild OA changes in ko and WT, no difference from WT

  • -

    At 2 years, cartilage damage score decreased in the lateral femoral condyle and overall joint score was also significantly decreased in ko mice; 25% reduction in VDIPEN staining; No significant differences in fibrosis or synovial infiltration

 Blom 2007
Mmp13 overexpressing FVB/N aging 5 months old cartilage, synovium
  • -

    Increased Mankin score for tibia and femur histopathology in the tg (included characteristic erosion of the articular cartilage associated with loss of proteoglycan and excessive cleavage of type II collagen by collagenase, as well as synovial hyperplasia)

  • -

    Increased collagen II cleavage associated with increased presence of MMP-13

 Neuhold 2001
Mmp13 overexpressing FVB/N aging 20 weeks old cartilage
  • -

    No spontaneous OA observed

 Glasson 2007
Mmp14 ko (MT1-MMP) ko Swiss Black mice aging up to day 40 joints
  • -

    At day 5, shorter limb bones

  • -

    At day 40 onwards, mice developed severe generalized arthritis. All joints showed overgrowth of a hypercellular, vascularized synovial tissue and destruction of articular cartilage, resulting in ankylosis. Tendons, ligaments, synovial capsules, musculotendinal junctions, and septal/fascial structures associated with skeletal muscle all displayed increased cell proliferation and vascularity, and became increasingly fibrotic.

 Holmbeck 1999
Ctsk overexpressing FVB/N aging 7, 12 months old cartilage, synovium
  • -

    At 7 months, no cartilage degradation

  • -

    At 12 months, severe degradation resulting from synovitis in tg mouse compared to WT; synovial hyperplasia, chondrocyte clusters at margins of articular surface and in menisci

 Morko 2005