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. Author manuscript; available in PMC: 2015 Mar 20.
Published in final edited form as: Mol Cell. 2014 Mar 13;53(6):1031–1043. doi: 10.1016/j.molcel.2014.02.013

Figure 6. Considering isoform ratios improves the model of miRNA targeting in non-cognate cell types.

Figure 6

(A) The performance of non-cell-type–specific wContext+ models for exogenous miRNAs. A comparison of performance of the original context+ model (dark blue), the cell-type–specific wContext+ model (pink) and the wContext+ model based on 3P-seq from other cell types (grey; error bars, standard deviation). Otherwise, as in Figure 3B.

(B) As in (A), but for endogenous targeting by murine miR-22.

(C) Non-cell-type–specific wContext+ model improves prediction of endogenous targeting mediated by miR-223 in neutrophils and miR-155 in B and Th1 cells. Otherwise, as in (A).