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. Author manuscript; available in PMC: 2014 Jul 25.
Published in final edited form as: J Med Chem. 2013 Jul 3;56(14):5917–5930. doi: 10.1021/jm4007017

Scheme 7.

Scheme 7

Reagents and conditions: a) (CF3SO2)2O, DMAP, DCM, 0 °C to rt, 15 min; b) 3-carbamoylphenylboronic acid, Na2CO3, PdCl2, EtOH, reflux, 12 h, 45%; c) BBr3, DCM, 0 °C to rt, 30 min, 40%; d) c-C6H11NCO, Et3N, CH3CN, reflux, 2 h, 65%.