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. Author manuscript; available in PMC: 2014 Jul 25.
Published in final edited form as: J Med Chem. 2013 Jul 3;56(14):5917–5930. doi: 10.1021/jm4007017

Figure 2.

Figure 2

Inhibition of brain FAAH activity by analogues of 3 bearing different substituents on the meta- position of the distal phenyl ring; a) Dose-dependent effects of secondary (7c), tertiary (7d) or reverse (7e) amide derivatives of compound 3 in Swiss Webster mice; doses were 0.3–40 mg/kg (subcutaneous); FAAH activity was measured ex vivo 1 h after injection; b) Dose-dependent effects of sulfonamide (7f) and methylsulfone (7g) derivatives of compound 3 in Swiss Webster mice; doses were 0.3–75 mg/kg (s.c.); c) Effects of pharmacological blockade of the Abcg2 transporter (Ko-143, 15 mg/kg, i.p., closed bars) on brain inhibition of FAAH activity by a sub-effective dose (selected from the dose-response study: 3 (25); 7d (10); 7e (1); 7f (40); 7g (1) in mg/kg, s.c., open bars) of analogues of compound 3 bearing different functionalities on the meta- position of the distal phenyl ring. Results are expressed as mean ± s.e.m. (n = 3-4). *** P< 0.001 vs non-Ko-143 treated group.