Scheme 3.
Reagents and conditions: a) i) m-CPBA, DCM, 40 °C, 72 h; ii) NaOCH3, EtOH, rt, 1 h, 60%; b) 3-carbamoylphenylboronic acid, Na2CO3, Pd(PPh3)4, toluene/H2O, reflux, 12 h, 81%; d) c-C6H11NCO, Et3N, CH3CN, reflux, 2 h, 77%.
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