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. 2012 Feb 15;22(1):63–75. doi: 10.11613/bm.2012.007

Table 1.

Xanthine oxidoreductase (XOR) isoforms and characteristic reactions (4,28).

Xanthine oxidase (XO) Xanthine dehydrogenase (XDH)
Hypoxanthine + H2O +2O2 →Xanthine + O2+ H2O2 Hypoxanthine+NAD+ +H2O→Xanthine+ NADH+ H+
Xanthine + H2O+2O2→Uric acid + O2+ H2O2 Xanthine + NAD++H2O→Uric acid+NADH+ H+
*

XDH prefers NAD+ as oxidizing substrate (but it is able to react with O2), while XO uses only O2