Table 1.
Xanthine oxidase (XO) | Xanthine dehydrogenase (XDH) |
---|---|
Hypoxanthine + H2O +2O2 →Xanthine + O2−+ H2O2 | Hypoxanthine+NAD+ +H2O→Xanthine+ NADH+ H+ |
Xanthine + H2O+2O2→Uric acid + O2−+ H2O2 | Xanthine + NAD++H2O→Uric acid+NADH+ H+ |
XDH prefers NAD+ as oxidizing substrate (but it is able to react with O2), while XO uses only O2