Table 2.

Some protective and pathogenic roles of uric acid (1,8,30).

	Protective	Pathogenic
Tissue	Serum	Intacellular milieu Atherosclerotic plaque Adipose tissue
Effects	Increasing of GSH in hippocampus	Mediating intermittent hypoxia-induced vascular dysfunction
	Sinergistic neuroprotection with plasmalogen	Inhibiting endothelial function by inhibition of NO-function under conditions of oxidative stress
	Free radical scavenger and a chelator of transitional metal ions	Surrogate marker for high levels of damaging oxidative stress associated with increased xanthine oxidase activity

GSH - glutathione; NO - nitric oxide