Table 2.
Comparison, within the same group, of GSH, TBARS, PC, vitamin E and ·NO levels and MPO and ADA activities, in the blood of chagasic patients at three different treatment times
| Group IA (n = 10) | Group IB (n = 20) | Group II (n = 8) | Group III (n = 4) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Untreated | After 6 months of treatmen with Carvedilol | After 6 months of combined treatment | Untreated | After 6 months of treatmen with Carvedilol | After 6 months of combined treatment | Untreated | After 6 months of treatmen with Carvedilol | After 6 months of combined treatment | Untreated | After 6 months of treatmen with Carvedilol | After 6 months of combined treatment | |
| TBARS | 13.11 ± 9.98 | 9.5 ± 4.28 | 6.10 ± 3.02β* | 10.02 ± 6.18 | 7.71 ± 1.17 | 6.52 ± 2.92β* | 11.34 ± 4.60 | 8.33 ± 1.55 | 7.13 ± 3.40 | 15.19 ± 5.04 | 9.50 ± 2.22 | 7.25 ± 4.06 |
| PC | 0.15 ± 0.07 | 0.04 ± 0.01a** | 0.09 ± 0.03β**Y** | 0.16 ± 0.19 | 0.05 ± 0.02a* | 0.09 ± 0.1β**Y*** | 0.17 ± 0.07 | 0.05 ± 0.01a*** | 0.10 ± 0.03β*Y*** | 0.15 ± 0.10 | 0.05 ± 0.01a* | 0.09 ± 0.12β*Y* |
| GSH | 0.31 ± 0.17 | 0.18 ± 0.12a* | 0.14 ± 0.10β** | 0.22 ± 0.17 | 0.16 ± 0.13a** | 0.11 ± 0.09β** | 0.29 ± 0.10 | 0.18 ± 0.11a* | 0.16 ± 0.06β* | 0.38 ± 0.15 | 0.16 ± 0.09*a | 0.18 ± 0.10β* |
| Vit. E | 17.36 ± 8.11 | 12.44 ± 2.85 | 16.18 ± 3.45Y* | 17.12 ± 8.93 | 15.70 ± 4.68 | 22.02 ± 11.0Y* | 19.64 ± 9.25 | 12.24 ± 2.18 | 29.40 ± 15.08Y* | 11.72 ± 3.40 | 11.18 ± 3.83 | 20.76 ± 3.38β*Y* |
| ADA | 10.03 ± 1.28 | 17.17 ± 2.5a* | 17.58 ± 2.21β* | 10.67 ± 1.08 | 15.36 ± 2.29 | 16.01 ± 0.92 | 14.02 ± 2.27 | 12.90 ± 2.14 | 14.94 ± 1.41 | 10.63 ± 3.52 | 9.05 ± 4.06 | 16.01 ± 0.59 |
| *NO | 10.93 ± 3.19 | 17.96 ± 3.2 a* | 9.09 ± 1.00Y* | 11.18 ± 1.38 | 16.07 ± 1.50 | 13.70 ± 1.53 | 15.49 ± 3.42 | 18.86 ± 2.60 | 17.17 ± 1.89 | 13.17 ± 4.62 | 12.10 ± 1.00 | 10.92 ± 1.98 |
| MPO | 417.3 ± 40.1 | 544.18 ± 70.05 | 553.96 ± 39.21 | 430.97 ± 31.53 | 420.70 ± 27.9 | 531.54 ± 25.84Y* | 409.54 ± 80.95 | 352.13 ± 50.36 | 707.42 ± 104.83β**Y*** | 440.92 ± 68.15 | 395.08 ± 60.10 | 559.04 ± 66.62 |
ADA: adenosine deaminase (UI-1); GSH: reduced glutathione (µmol ml-1); PC: protein carbonyl (nmol mg-1); *NO: nitric oxide (µM); MPO: myeloperoxidase (mU ml-1); TBARS: thiobarbituric-acid reactive substances (nmol ml-1); vitamin E (µmol ml-1).
Values are expressed as mean ± standard deviation *p < 0.05, **p < 0.01,***p < 0.001 represent significant differences within the same chagasic group.