Table 4. Association analysis of rs9276370 with clinical classifications in HBsAg positive carriers.
Clinical characteristic | Genotype Frequency for the group of interest | MAF | Genotype Frequency for the other two groups | MAF | Trend test P-value | Testing for mode of inheritance | P-valuea | OR (95% CI)a | ||||
GG | GT | TT | GG | GT | TT | |||||||
PNALT | 0.011 | 0.164 | 0.825 | 0.093 | 0.004 | 0.132 | 0.865 | 0.069 | 0.0241 | Additive | 0.0376 | 0.73 (0.55–0.96) |
Dominant | 0.0667 | 1.32 (0.98–1.78) | ||||||||||
Recessive | 0.0947 | 3.09 (0.82–11.63) | ||||||||||
CHB | 0.000 | 0.146 | 0.854 | 0.073 | 0.011 | 0.136 | 0.853 | 0.079 | 0.5247 | Additive | 0.3746 | 1.13 (0.87–1.47) |
Dominant | 0.7610 | 0.96 (0.72–1.27) | ||||||||||
Recessive | 0.9719 | N/A | ||||||||||
HCC | 0.011 | 0.101 | 0.888 | 0.062 | 0.004 | 0.153 | 0.843 | 0.080 | 0.0923 | Additive | 0.2134 | 1.25 (0.88–1.76) |
Dominant | 0.0903 | 1.38 (0.95–2.00) | ||||||||||
Recessive | 0.0896 | 3.25 (0.83–12.70) |
ORs and CIs were calculated by setting the T allele as the reference with age adjustment.